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KMID : 0360220100510040542
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Journal of the Korean Ophthalmological Society
2010 Volume.51 No. 4 p.542 ~ p.551
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Incidence (1991~1993) and Survival Rates (1991-2003) of Retinoblastoma in Korea
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Kim Jeong-Hun
Yu Young-Suk
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Abstract
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Purpose: To determine the incidence (1991~1993) and survival rates (1991~2003) of retinoblastoma in Korea.
Methods: Data of all Korean patients diagnosed with retinoblastoma from 1991-1993 were retrospectively collected by the hospital- based national registry based on notifications from physicians who are able to diagnose retinoblastoma. The incidence rate (1991~1993) was calculated per 100,000 childbirths (dividing the number of retinoblastoma patients by the total number of childbirths). The survival rate (1991~2003) was calculated using the Kaplan?Meier method, and the differences were evaluated with the logrank and Wilcoxon tests and Cox’s proportional hazards model.In addition, the clinical findings and prognostic factors associated with survival rate were analyzed.
Results: There were a total of 108 distinct patients diagnosed with retinoblastoma in the registry. The incidence of retinoblastoma in Koreawas 4.99 per 100,000 childbirths, and the survival rate for 13 years (1991-2003) was 77.8%. The survival rate was significantly lower in the population of bilateral retinoblastomapatients, as compared to unilateral retinoblastoma patients. Optic nerve invasion was found to be an independent variable for the reduction of survival rate, although its effects were not significant.
Conclusions: In the present study, the incidence and survival rates of retinoblastoma in Koreawere presented for the first time. The incidence rate was similar to rates reported from other countries. On the other hand, the survival rate was lower than those in European and the United States. In particularly, the survival rate was significantly lower in patients with bilateral retinoblastoma.
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KEYWORD
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Incidence rate, Retinoblastoma, Survival rate
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